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Despite these health, safety, and quality of life consequences, there are no FDA-approved therapies for several forms of central hypersomnia, including idiopathic hypersomnia (IH).

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Although the majority of patients with CF from whom NTM are recovered will likely not meet microbiologic criteria for disease at the time of an initial positive culture, close surveillance of these patients is warranted.

The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.

The long-term success rate in the macrolide era for salvage regimens, without surgery, for treating macrolide-resistant disease is very poor.

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Exacerbation of symptoms of myasthenia gravis and new onset of symptoms of myasthenic syndrome has been reported in patients receiving Clarithromycin therapy.

But there is evidence that people with some conditions benefit even if they know they are taking placebos.

In clinical trials using combination therapy with Lansoprazole plus amoxicillin and clarithromycin, and Lansoprazole plus amoxicillin, no increased laboratory abnormalities particular to these drug combinations were observed.

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Of the cases cited, 59% involved tenosynovitis, and 26% were associated with pulmonary disease.

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Cases of torsades de pointes have been spontaneously reported during postmarketing surveillance in patients receiving BIAXIN.

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In comparing the clarithromycin and azithromycin trial results, note that the CCTG trial patients began with a higher median CD4 count and had a shorter follow-up period; therefore, they were probably at lower risk.

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HIV-negative patients with MAC lung disease ().

Biaxin is effective against Haemophilus influenzae, Streptococcus pneumoniae, Mycoplasma pneumoniae, Staphylococcus aureus, mycobacterium avium, and many others so it is used to treat many kinds of bacterial infections of skin and respiratory system, stomach ulcers caused by Helicobacter pylori.

QT prolongation, ventricular tachycardia, ventricular fibrillation, and torsades de pointes) most likely due to inhibition of metabolism of these drugs by erythromycin and Clarithromycin.

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Never happy taking antibiotics but sometimes we just have to go down that route.

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Macrolide resistance of Staphylococcus aureus and Haemophilus species associated with long-term azithromycin use in cystic fibrosis.

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In the clarithromycin group, there was a decrease in the proinflammatory cytokine IL-6, an increase in the anti-inflammatory cytokine IL-10, and an increase of IFN-γ ().

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If this treatment provides insufficient clinical benefits after 6 months of therapy or if undesirable adverse effects are associated with this drug, clarithromycin at 200 or 400 mg daily or roxithromycin at 150 or 300 mg daily is then recommended ().

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Itraconazole: Both clarithromycin and itraconazole are substrates and inhibitors of CYP3A, potentially leading to a bi-directional drug interaction when administered concomitantly.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease (including liver problems with past clarithromycin use), kidney disease, a certain type of muscle disease (myasthenia gravis), a certain type of viral infection (infectious mononucleosis).

One year later a systematic review was published based on data from 16 of 172 arms where proton pump inhibitor-clarithromycin-amoxicillin therapy was given, and for which susceptibility testing was performed.

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The recommended adult dose is 500 mg BIAXIN given twice daily (q12h) or three times daily (q8h) and 400 mg ranitidine bismuth citrate given twice daily (q12h) for 14 days.

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Clarithromycin in treatment of early Lyme disease: a pilot study.

Lymphoid depletion occurred in dogs at doses 3 times greater than and in monkeys at doses 2 times greater than the maximum human daily dose (on a body surface area basis).

Hawksworth G, McArdle K. Metabolism and pharmacokinetics of cannabinoids. In: Whittle BA, Guy GW, Robson PJ, eds.

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The treatment regimen for disseminated MAC should include at least 2 drugs to prevent emergence of resistance.

Median duration of BIAXIN was 10.

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Clarithromycin and its primary, active metabolite are both eliminated by the kidney to some extent.

When 250 mg doses of clarithromycin as BIAXIN as an oral suspension were administered to fasting healthy adult subjects, peak plasma concentrations were attained around 3 hours after dosing.

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This patient population had a high incidence of TB and HIV infection; therefore, most patients (70%) were started on empiric anti-TB therapy before species identification of the mycobacterial isolate.

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Children with NTM lymphadenitis tested with intermediate strength (5 tuberculin unit) PPD tuberculin have a range of reactions from negative to positive; up to one-third in one series showed reactions of 10 mm or more of induration ().

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In summary, there are clear and compelling data demonstrating that the 14- and 15-membered (but not the 16-membered) macrolide antibiotics can decrease the hypersecretion of proinflammatory cytokines and chemokines in cell culture, in animal models of disease, and in persons with chronic inflammatory pulmonary diseases.

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Patients treated with any Lansoprazole dose reported significantly less day and night abdominal pain along with fewer days of antacid use and fewer antacid tablets used per day than the placebo group.

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Fortunately, breakthrough with macrolide-resistant mycobacteremia has been a rare event in the prophylaxis trials just described; only 2-3% of patients given clarithromycin and only 1% of patients given azithromycin had "breakthrough" mycobacteremia with MAC isolates that were resistant to these drugs.

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Shinkai and associates () focused on the ERK pathway and evaluated effects of macrolides on IL-8 and GM-CSF release from NHBE cells in culture.

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