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Older adults are more sensitive to the side effects, such as poorer blood sugar control or confusion of the drug.

Your doctor may prescribe HCTZ to reduce blood pressure or control edema, or water retention, associated with heart failure or another medical condition.

These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including losartan and hydrochlorothiazide.

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Cozaar (losartan) is the brand name for another drug very similar to Diovan.

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It is in the class of medications called ACE inhibitors that work by causing blood vessels to relax.

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In the controlled clinical trials of valsartan and hydrochlorothiazide, 764 (17.

Losartan pharmacokinetics have been investigated in the elderly (65 to 75 years) and in both genders.

Combination therapy in hypertension: From effect on arterial stiffness and central haemodynamics to cardiovascular benefits.

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The difference in CVEs between the 2 drugs does not appear until about 9 months (see their Figure 1), implying that half of the impact of chlorthalidone is not reflected in the hazard ratio (HR).

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